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. Author manuscript; available in PMC: 2008 Jul 8.
Published in final edited form as: Angew Chem Int Ed Engl. 2008;47(13):2394–2397. doi: 10.1002/anie.200704847

Scheme 1.

Scheme 1

Synthesis of phosphine 1. Reagents and conditions: a) tBuOH, DMAP (0.5 equiv), EDAC, CH2Cl2 (84%); b) LiOH (1.5 equiv), 3:1 MeOH:H2O (94%); c) HPPh2, K2CO3, Pd(OAc)2 (0.3 mol %), CH3CN, reflux (72%); d) disperse red 1, DMAP (0.1 equiv), DCC, CH3CN (83%); e) TFA (26 equiv), TES (5 equiv), CH2Cl2 (87%); f) 8, HATU, DIPEA, DMF (65%).