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The influence of chronic stimulation with viral antigen on the diversity of the CD4 TCR repertoire. Frequencies of 17 BV8-BJ1S4 TCR β-chains from three patients with chronic hepatitis C infection were determined by limiting dilution analysis. Distributions of TCR β-chain frequencies in CD4 T cells are shown in comparison to normal donors and RA patients. The chronic antiviral response did not alter the diversity of the CD4 T cell repertoire.
