Figure 6. MsrA−/− mice have increased susceptibility to AngII-mediated apoptosis.

(A) Immunofluorescent staining of heart sections from WT and MsrA−/− mice treated with AngII and probed for oxidized or total CaMKII. Red staining is positive for oxidized or total CaMKII and blue staining is for nuclei. Calibration bars are 100 microns. (B) Quantification of average staining intensity for AngII treated hearts, relative to WT (n = 3 hearts/group, * p < 0.05 vs. WT with AngII). (C) Summary data for TUNEL staining of heart sections from WT and MsrA−/− mice treated with saline or AngII (n = 5 hearts/group, * p < 0.05 vs. WT with saline).