Fig. 3.
ADAM17, EGFR, p-EGFR, Akt, p-Akt expression in normal brain. The positive ADAM17-immunoreactive area within the area of PDT treatment and contralateral were analyzed by MCID. 80J/cm2 PDT significantly increased ADAM17 positive area (10.89%) compared to contralateral (1.78%) The number of EGFR, P-EGFR, Akt, pAkt–immunoreactive cells were counted in each section. There were no significant changes in the expression of total EGFR or Akt in the area of PDT treatment and contralateral tissue. p-EGFR and p-Akt positive cells percentage increased from 9.50% and 14.50% to 21.31% and 32.29%, respectively, in the PDT-treated area compared to the contralateral. tissue. Bar is 50μm. **,P<0.01, n=5