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Simulation results of phase IV drop-the-loser design
| Interim sample size per group | Final sample size per group | Probability of identifying the optimal arm |
| 25 | 50 | 80.3% |
| 50 | 100 | 91.3% |
Note: response rate for the five arms: 0.4, 0.45, 0.45, 0.5, and 0.6.
