TABLE 3.
Final parameter values estimated by use of the modela
| Parameter | Typical valueb | % RSEc | 95% CId |
|---|---|---|---|
| CL/F (liters · h−1) | 19.2 | 1.29 | 18.4-20.0 |
| V/F (liters) | 53.2 | 1.16 | 51.1-54.3 |
| ka (h−1) | 1.15 | 3.91 | 1.05-1.25 |
| MTT (h) | 0.424 | 3.82 | 0.400-0.459 |
| No. of transit compartments (n) | 7.13 | 8.42 | 5.17-7.13 |
| θSDF-CL/F | 0.236 | 9.63 | 0.160-0.283 |
| θSDF-MTT | 1.04 | 8.78 | 0.791-1.24 |
| IIV (variances plus % CV) | |||
| ηCL/F | 0.279 (52.8%) | 5.97 | 0.242-0.347 |
| ηV/F | 0.188 (43.4%) | 10.9 | 0.154-0.250 |
| ηka | 0.439 (66.3%) | 11.0 | 0.324-0.506 |
| ηMTT | 0.361 (60.1%) | 7.87 | 0.266-0.411 |
| ηn | 2.44 (156%) | 13.7 | 1.84-3.39 |
| Covariance ηCL/F ∼ ηV/F (covariance and correlation) | 0.217 (0.947) | 7.45 | 0.186-0.267 |
| IOV (variances plus % CV) | |||
| κCL/F | 0.0508 (22.5%) | 10.9 | 0.0413-0.0724 |
| κMTT | 0.461 (67.9%) | 11.3 | 0.401-0.590 |
| Residual variability | |||
| Additive error (ɛadd [mg liter−1]) | 0.0923 | 5.41 | 0.0790-0.103 |
| Proportional error (ɛccv) | 0.222 | 2.89 | 0.207-0.238 |
a
Assessed by nonparametric bootstrap method; n = 800 iterations. Runs without successful conclusion (“MINIMIZATION SUCCESSFUL”) were omitted from analysis (n = 52); 748 runs in total are included.
b
Values in parentheses represent percentages of the total, with the exception of the value in parentheses for ηCL/F ∼ ηV/F.
c
RSE, relative standard error.
d
CI, confidence interval.