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. Author manuscript; available in PMC: 2009 May 2.
Published in final edited form as: Cell. 2008 May 2;133(3):415–426. doi: 10.1016/j.cell.2008.03.026

Figure 6. Hypersensitivity of TIPE2 knockout mice to septic shock.

Figure 6

Wild type (n=11) and TIPE2-deficient littermates (n=10), 5–6 weeks of age, were injected intravenously with a low dose LPS (15 mg/kg). A. The survival curves. B. IL-1β, IL-6, IL-12p40 and TNF-α concentrations in the sera as determined by ELISA. For the LPS treated group, mice were injected with LPS as in panel A, and sera were collected 48 hrs later. For the untreated group, sera were collected from age and sex matched naïve mice (n=6). Data shown are means and SD, and are representative of two experiments.