Figure 1.
This series of low-power images depicts αS, βS, and γS immunoreactivity in hippocampus and entorhinal cortex of normal control (Top), DLB (Middle), and PD (Bottom) brains. The first column demonstrates the normal αS neuropil staining pattern (A) compared with the DLB (B) and PD (C) entorhinal cortex with αS-positive LBs using the LB509 antibody to αS. The second column shows the normal αS neuropil staining pattern (D) and dystrophic Lewy neurites in the CA2/3 region of hippocampus in the DLB case (E) and to a lesser extent in PD (F) by using LB509. The third column shows the normal αS neuropil staining pattern (G) and degenerate mossy fiber terminals around hilar neurons in DLB (H) and PD (I) by using LB509. The fourth column shows the normal αS neuropil staining pattern (J) as well as degenerate mossy fibers in DLB (K) and PD (L) by using the Syn207 antibody to βS. The final column shows the normal αS neuropil staining pattern (M) and depicts degenerate terminals in the stratum moleculare of the dentate gyrus in DLB (N) and PD (O) by using antisera 20 to γS. All panels are at the same magnification, and the scale bar in O = 20 μm.