Figure 6.
Targets of E2 signaling participate in epigenetic regulation. Targets of E2 signaling involved in epigenetic regulation of gene expression were observed. These chromatin factors include the components in Polycomb group (PcG) complexes, DNA methyltransferases and methyl-DNA-binding proteins, histone modifiers, histone chaperones, variant histones, and proteins maintaining higher-order chromatin structure. Gene expression changes upon E2 treatment are color-coded (log2-transformed fold changes). Genes for which ERα or MYC binding was detected (ChIP-chip sites) are indicated and the location of the binding site relative to the TSS is depicted (see color legend).