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LT activation of caspase-1 requires proteasome activity subsequent to LF-mediated proteolytic events. (A) Macrophages treated with LT or S. typhimurium (S.T) in the presence of proteasome inhibitors (1 μM MG-132 or 5 μM lactacystin) were examined for active caspase-1 by FAM-YVAD staining; means ± SD are shown. *, P < 0.05 versus medium. (B) Mature IL-18 was detected in supernatants by Western blot. (C) Cleaved MEK3 (arrow) in LT intoxicated macrophages was detected as in Fig. 3.
