Table 1.
Phenotype analysis of LPS-treated wild-type (C57/B6J) Opn knockout (Spp1−/−) micea
| Group | n | Age (wk) | Body Weight (g) | Albumin/Creatinine (μg/mg) |
|---|---|---|---|---|
| C57/B6 | 9 | 6 | 20.9 ± 2.0 | 71.6 ± 23.0 |
| C57/B6 LPS | 10 | 6 | 20.4 ± 1.0 | 292.4 ± 37.0b |
| Spp1−/− | 8 | 6 | 19.9 ± 1.0 | 63.4 ± 23.0 |
| Spp1−/− LPS | 10 | 6 | 21.8 ± 1.0 | 91.8 ± 35.0 |
a
Body weight and albuminuria were measured at the time animals were killed, 24 h after LPS injection. Albuminuria was measured by murine albumin-specific ELISA kit and creatinine with colorimetric reaction and expressed as μg albumin/mg creatinine.
b
Statistically significant difference, P < 0.05 versus C57/B6 control groups.