. Author manuscript; available in PMC: 2008 May 2.

Published in final edited form as: Am J Ophthalmol. 2007 Feb 5;143(4):607–615. doi: 10.1016/j.ajo.2006.12.006

TABLE 2.

Transcription Factors and Gene Product, Measured in Response to Oxidative Stress in the Retinal Pigment Epithelium in Age-Related Macular Degeneration

Redox Sensitive Transcription Factors	Target Gene Products
FOXO⁵²,⁶⁶–⁶⁸	MnSOD	Catalase	InR
NF-kB⁵²,⁶⁶,⁶⁹	MnSOD	Catalase	CuZnSOD
Nrf-2⁷⁰	MnSOD	Alpha 6	Alpha 7	HSP90
HSF-1⁷¹,⁷²	HSP27	HSP70

FOXO = forkhead box O 3A; Nrf-2 = nuclear factor-2; MnSOD = manganese superoxide dismutase; NF-kB = nuclear factor kappa-beta; CuZnSOD = copper-zinc superoxide disumutase; HSP = heat shock protein; HSF-1 = heat shock factor; InR = insulin receptor.