Table 2. BUPA study: odds of prostate, colorectal, and lung cancer according to quartiles of serum levels of IGF-1, IGF-2 and IGFBP-3 within the first 15 years of follow-up (follow-up being the time between sample collection and diagnosis).
|
Adjusted odds ratiosa
|
||||||
|---|---|---|---|---|---|---|
|
Quartile groups
|
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| Site of cancer | Analyte | 1 (ref) | 2 | 3 | 4 (95% CI) | P for trend |
| Prostate | ||||||
| IGF-1 | 1 | 0.96 | 0.61 | 1.37 (0.76–2.49) | 0.62 | |
| IGF-2 | 1 | 1.18 | 1.49 | 1.47 (0.77–2.81) | 0.19 | |
| IBFBP-3 | 1 | 1.09 | 0.84 | 1.40 (0.77–2.55) | 0.42 | |
| Colorectal | ||||||
| IGF-1 | 1 | 1.20 | 1.39 | 1.10 (0.56–2.18) | 0.65 | |
| IGF-2 | 1 | 1.70 | 1.84 | 1.59 (0.67–3.75) | 0.40 | |
| IBFBP-3 | 1 | 0.90 | 1.06 | 0.72 (0.37–1.37) | 0.46 | |
| Lung | ||||||
| IGF-1 | 1 | 1.00 | 1.23 | 1.21 (0.62–2.35) | 0.45 | |
| IGF-2 | 1 | 1.21 | 1.22 | 0.82 (0.39–1.73) | 0.61 | |
| IBFBP-3 | 1 | 0.90 | 1.39 | 1.70 (0.87–3.30) | 0.06 | |
a
The odds ratios were adjusted for age by matching and were also adjusted: smoking for lung cancer and smoking, alcohol and body mass index for colon and rectum.