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. 2007 Jan 23;96(2):373–382. doi: 10.1038/sj.bjc.6603563

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Copyright © 2007 Cancer Research UK

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SEC11L3 mRNA expression in non-neoplastic epithelial cells and PDAC cells, as determined by ISH. (A) Strong expression (score 2) in both ductal (white arrows) and acinar cells of non-neoplastic pancreas. (B) ISH conducted with a sense SEC11L3 riboprobe, used as a negative control. (C–E). No expression (score 0) in PDAC cells (black arrows), but weak expression (score 1) in non-neoplastic islet cells (black arrow heads) (PC41 and 47) (F). Weak expression (score 1) of PDAC cells in PC43 and (G) strong intensity of expression (score 2) of PDAC cells in PC44. (H) Lower level of expression (score 1; PC53) and (I) similar intensity of expression (score 2; PC55) in metastatic PDAC cells (black arrows) compared to non-neoplastic hepatic cells (asterisk).