Table 1.
Changes in diabetes medication of 19 overweight participants with type 2 diabetes who underwent a 16-week diet intervention trial. Patients were provided with VLCKD counseling with an initial goal of <20 g carbohydrate/day. Medication was reduced at diet initiation. Data from Yancy, et al. [62].
| Patient number | Daily Dose – Week 0 | Daily Dose – Week 16 |
| Medications discontinued (n = 7 of 19 originally on medication) | ||
| 5 | glipizide 10 mg | none |
| metformin 1000 mg | ||
| 6 | metformin 1500 mg | none |
| 7 | none | |
| 9 | metformin 1000 mg | none |
| 15 | metformin 1000 mg | none |
| 22 | metformin 1000 mg | none |
| 24 | metformin 1000 mg | none |
| Medications reduced (n = 10 of 19) | ||
| 3 | 70/30 insulin 50 units | metformin 1000 mg |
| metformin 1000 mg | ||
| 11 | metformin 2000 mg | metformin 2000 mg |
| glyburide 20 mg | ||
| 16 | metformin 2000 mg | metformin 2000 mg |
| pioglitazone 45 mg | ||
| glypizide 20 mg | ||
| 21 | metformin 1500 mg | metformin 1000 mg |
| pioglitazone 30 mg | ||
| 8 | NPH 145 units | NPH 25 units |
| metformin 1000 mg | metformin 1000 mg | |
| 13 | 70/30 insulin 70 units | 70/30 insulin 35 units |
| metformin 2550 mg | metformin 2550 mg | |
| 23 | 70/30 insulin 110 units | 70/30 insulin 80 units |
| pioglitazone 45 mg | pioglitazone 45 mg | |
| metformin 1000 mg | ||
| 25 | NPH 70 units, r 30 units | NPH 8 units |
| metformin 2000 mg | metformin 2000 mg | |
| pioglitazone 45 mg | pioglitazone 45 mg | |
| 27 | 70/30 insulin 86 units | 70/30 insulin 18 units |
| metformin 2000 mg | metformin 2000 mg | |
| 28 | NPH insulin 90 units | NPH insulin 30 units |
| lispro insulin 90 units | glypizide 20 mg | |
| glypizide 20 mg | ||