Table 1.
Ability of AddlE1–B7-1, AdMEM12R and AdIL12–B7-1 to induce tumor regression following a single intratumoral injection
| Virus | Exp. | Response
|
|||
|---|---|---|---|---|---|
| None* | Growth delay† | Partial‡ | Complete§ | ||
| AddlE1–B7-1 | 1 | 0 | 5 | 0 | 0 |
| (2.5 × 107) | 2 | 1 | 4 | 0 | 0 |
| 3 | 0 | 5 | 0 | 0 | |
| Total | (1/15) | (14/15) | |||
| AdMEM12R | 1 | 1 | 4 | 0 | 0 |
| (2.5 × 107) | 2 | 1 | 4 | 0 | 0 |
| 3 | 0 | 5 | 0 | 0 | |
| Total | (2/15) | (13/15) | |||
| AddlE1–B7-1 | 1 | 0 | 2 | 1 | 2 |
| AdMEM12R | 2 | 0 | 4 | 0 | 1 |
| (2.5 × 107) | Total | (6/10) | (1/10) | (3/10) | |
| AdIL12–B7-1 | 1 | 0 | 1 | 0 | 4 |
| (2.5 × 107) | 2 | 1 | 1 | 0 | 3 |
| 3 | 0 | 3 | 0 | 7 | |
| Total | (1/20) | (5/20) | (14/20) | ||
| AdIL12–B7-1 | 1 | 0 | 3 | 2 | 0 |
| (1 × 107) | 2 | 0 | 2 | 3 | 0 |
| Total | (5/10) | (5/10) | |||
| AdIL12–B7-1 | 1 | 0 | 0 | 0 | 5 |
| (1 × 108) | 2 | 0 | 0 | 1 | 4 |
| Total | (1/10) | (9/10) | |||
*
Tumor development following injection not significantly different from mice treated with control Addl70-3.
†
Slight decrease in tumor volume and/or tumor growth significantly delayed and animals survived 2-8 weeks longer than controls.
‡
Tumors completely regressed for at least 2 weeks.
§
Tumors completely regressed and did not reoccur.