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. 2003 Oct;77(19):10488–10503. doi: 10.1128/JVI.77.19.10488-10503.2003

TABLE 2.

Transcript abundance during MHV-68 infection

Probe Function Transcript abundancea
Normalized data at:
 Rank at:
 Normalized data
 Normalized data
4 h 8 h 12 h 24 h 32 h Lung 5d 4 h 8 h 12 h 24 h 32 h Lung 5d +CHX −CHX +PAA −PAA
vtRNA vtRNA ND 0.52 1.47 1.47 3.98 0.35 50 58 59 60 5 0.07 0.13 0.87 4.40
M1 Serpin ND 0.15 0.36 0.33 0.70 0.59 6 13 15 9 15 ND 0.07 0.99 1.21
M2 Unknown ND 0.30 0.57 0.45 1.38 1.32 27 30 21 31 49 ND 0.12 2.23 2.24
M3 Chemokine binding protein 0.18 5.53 11.73 10.79 16.29 13.71 5 83 80 79 75 81 ND 10.79 68.30 44.42
M4 Unknown ND 0.53 0.96 0.53 1.43 0.74 53 50 28 33 22 0.32 1.06 11.26 1.81
ORF 4 Complement regulatory protein ND 0.29 0.75 0.82 1.27 1.01 26 40 45 29 40 ND 0.10 0.81 1.09
ORF 6-5′ ssDNA-binding protein ND 0.40 0.49 0.60 1.18 0.58 40 25 31 26 14 ND 0.14 0.78 1.24
ORF 6-3′ ssDNA-binding protein ND 0.38 0.63 0.51 0.95 0.54 36 34 26 20 11 ND 0.74 2.17 2.29
ORF 7 Transport protein 0.14 2.89 7.01 5.65 16.53 8.43 4 76 77 75 76 78 0.16 7.10 6.92 9.96
ORF 8-5′ Glycoprotein B ND 0.26 0.77 0.64 1.54 0.69 19 43 35 35 21 ND 0.10 1.21 1.43
ORF 8-3′ Glycoprotein B ND 0.71 1.95 1.37 3.10 1.76 61 63 58 57 60 ND 0.56 2.54 3.97
ORF 9-5′ DNA polymerase ND 0.13 0.33 0.16 0.50 0.62 4 11 1 3 17 ND 0.06 0.87 1.16
ORF 9-3′ DNA polymerase ND 0.06 0.32 0.27 0.48 0.56 1 8 7 2 13 ND 0.06 1.09 1.14
ORF 10 Unknown ND 0.57 1.06 0.48 1.20 0.85 54 51 23 27 31 0.01 0.59 2.90 2.31
ORF 11 Unknown ND 1.32 3.28 1.97 3.05 1.68 72 70 63 56 57 0.04 1.27 3.86 5.19
K3 Modulator of immune response ND 1.42 4.59 5.81 8.97 4.91 74 73 76 71 73 0.21 1.08 6.96 11.64
M5 Unknown ND 0.65 2.17 3.45 5.90 2.78 58 64 69 67 66 0.05 0.45 5.76 11.33
ORF 17 Capsid protein ND 0.45 1.56 1.90 2.13 0.84 42 59 62 44 30 ND 0.28 2.85 1.65
ORF 18 Unknown ND 1.10 1.67 1.33 1.62 1.03 68 61 57 39 41 0.04 1.67 30.58 5.78
ORF 19 Tegument protein ND 0.83 1.46 0.80 2.18 1.11 64 57 44 46 46 ND 0.46 1.23 2.38
ORF 20 Unknown ND 0.29 0.45 0.27 1.00 1.10 25 20 10 22 44 ND 0.13 1.54 1.93
ORF 21 Thymidine kinase ND 0.29 0.43 0.22 0.79 0.55 24 17 4 13 12 ND 0.13 1.39 1.49
ORF 22 Glycoprotein H ND 0.48 1.41 0.48 1.96 1.63 47 56 22 42 54 0.02 0.38 3.09 2.92
ORF 23 Unknown ND 0.52 1.35 0.62 2.46 1.87 51 55 34 51 61 0.03 0.38 1.52 2.81
ORF 24 Unknown ND 0.18 0.41 0.27 0.73 0.65 11 16 8 11 18 ND 0.08 0.94 1.35
ORF 25-5′ Major capsid protein ND 0.13 0.23 0.31 0.58 0.32 3 2 13 4 3 ND 0.05 0.36 0.77
ORF 25-3′ Major capsid protein ND 0.19 0.43 0.76 0.70 0.61 13 18 41 8 16 ND 0.04 1.00 1.53
ORF 26 Capsid protein ND 0.84 3.21 2.96 6.17 2.54 65 69 67 68 64 ND 0.38 3.17 6.13
ORF 27 Unknown ND 0.49 2.20 5.46 6.26 2.70 48 65 74 69 65 0.04 0.99 5.15 11.67
ORF 29b Packaging protein ND 0.32 0.69 1.10 1.88 0.95 32 35 55 41 37 0.04 0.21 2.13 3.14
ORF 30 Unknown ND 0.28 0.56 0.34 1.57 0.85 21 27 17 38 32 ND 0.20 3.47 4.92
ORF 31 Unknown ND 0.25 0.34 0.33 1.00 0.67 18 12 16 21 20 ND 0.15 1.59 2.28
ORF 32 Unknown ND 0.23 0.32 0.32 0.79 0.76 17 7 14 12 24 ND 0.11 0.99 1.55
ORF 33 Unknown ND 0.50 0.69 0.78 2.26 0.88 49 37 43 48 36 ND 0.61 4.59 6.09
ORF 29a Packaging protein ND 1.31 2.21 1.09 5.43 3.09 71 66 54 64 69 ND 0.79 4.58 7.68
ORF 34 Unknown ND 0.16 0.24 0.25 0.79 0.65 8 4 5 14 19 ND 0.07 1.05 1.04
ORF 35 Unknown ND 0.43 0.75 0.90 2.90 1.37 41 41 47 54 51 0.04 0.24 4.25 7.03
ORF 36 Kinase ND 0.16 0.33 0.40 0.81 0.52 7 10 19 15 10 ND 0.08 0.97 1.47
ORF 37 Alkaline exonuclease ND 0.32 0.47 0.73 0.89 ND 31 23 40 17 1 0.06 0.28 2.04 2.09
ORF 39 Glycoprotein M ND 1.78 7.31 11.14 18.82 7.16 75 78 80 77 76 0.07 1.21 8.78 14.03
ORF 40 Helicase-primase ND 1.11 6.41 10.60 19.90 8.29 69 75 78 78 77 0.02 0.98 7.48 13.93
ORF 42 Tegument ND 0.52 1.21 1.78 3.02 1.05 52 53 61 55 43 0.03 0.51 4.63 4.82
ORF 43 Capsid protein ND 0.13 0.23 0.27 0.66 0.45 5 3 9 6 6 ND 0.07 0.80 1.27
ORF 44-5′ Helicase-primase ND 0.22 0.46 0.65 1.57 1.13 16 22 36 37 47 0.03 0.13 1.60 2.62
ORF 44-3′ Helicase-primase ND 0.19 0.24 0.48 0.72 0.35 12 5 24 10 4 0.03 0.15 1.02 1.91
ORF 45 Unknown ND 3.57 5.35 5.11 21.38 10.70 81 74 73 79 79 0.07 1.63 9.53 14.02
ORF 46 Uracil DNA glycosylase ND 0.45 0.71 0.71 2.18 0.84 44 38 38 45 29 ND 0.36 4.91 4.15
ORF 47 Glycoprotein L ND 0.65 0.87 0.61 2.03 1.41 59 46 32 43 52 0.08 1.04 7.56 2.63
ORF 48 Unknown ND 0.37 0.53 0.67 1.43 0.77 35 26 37 34 25 0.05 1.38 13.58 3.30
ORF 49 Unknown ND 0.16 0.27 0.39 0.65 0.46 9 6 18 5 7 ND 0.10 1.59 1.42
ORF 50 Transcriptional activator ND 0.20 0.37 0.27 1.03 0.50 14 14 11 23 8 0.16 0.19 1.77 1.34
M7 Glycoprotein 150 ND 3.10 12.17 13.72 29.93 11.63 78 81 81 81 80 0.09 1.73 11.63 19.40
ORF 52 Unknown ND 3.19 15.60 26.93 53.79 17.20 79 83 82 82 82 0.05 1.97 14.46 21.60
ORF 53 Unknown ND 0.48 1.64 2.47 5.54 0.88 46 60 64 65 35 0.05 0.44 4.88 5.23
ORF 54 dUTPase 0.13 0.45 0.69 0.20 0.95 1.04 3 43 36 3 18 42 ND 1.48 3.48 2.75
ORF 55 Unknown ND 0.36 0.57 0.98 1.64 1.42 34 28 49 40 53 0.02 0.38 1.86 3.00
ORF 56-5′ Helicase-primase ND 0.08 0.09 0.16 0.30 0.30 2 1 2 1 2 ND 0.05 0.38 0.93
ORF 56-3′ Helicase-primase ND 0.17 0.32 0.28 0.87 0.84 10 9 12 16 28 ND 0.08 1.06 1.43
M8 Unknown ND 0.72 0.94 0.57 2.61 2.79 62 48 30 52 67 0.07 0.63 5.74 6.17
ORF 57 Posttranscriptional regulator 0.12 0.78 0.94 0.61 3.49 1.75 2 63 49 33 58 59 0.44 1.39 5.45 3.87
ORF 58 Unknown ND 0.30 0.46 0.78 1.54 0.99 29 21 42 36 39 0.02 0.11 2.16 2.84
ORF 59 Processivity factor ND 0.69 0.74 0.85 1.12 0.87 60 39 46 25 34 0.03 2.67 13.79 2.61
ORF 60 Ribonucleotide reductase (small) ND 0.30 0.47 0.54 1.36 0.96 28 24 29 30 38 0.01 0.10 1.72 1.81
ORF 61 Ribonucleotide reductase (large) 0.28 3.23 6.48 5.05 16.07 6.50 8 80 76 72 74 74 0.05 2.33 5.26 9.63
ORF 62 Assembly/DNA maturation ND 0.63 2.43 3.41 7.41 3.13 57 67 68 70 70 0.03 0.40 2.42 5.75/PICK>
ORF 63 Tegument protein ND 0.34 0.90 1.04 2.32 0.87 33 47 52 49 33 ND 0.09 1.07 1.26
ORF 64-5′ Tegument protein 0.38 0.30 0.59 0.49 0.69 1.10 10 30 32 25 7 45 ND 0.07 1.19 1.42
ORF 64-3′ Tegument protein ND 0.27 0.63 1.01 1.41 1.16 20 33 50 32 48 ND 0.29 1.75 3.64
ORF 65 (M9) Capsid protein ND 5.14 13.96 28.05 64.10 22.55 82 82 83 83 83 0.15 22.19 154.13 268.20
ORF 66 Unknown ND 0.85 1.92 4.48 13.83 2.21 66 62 70 73 63 0.03 1.29 16.44 26.19
ORF 67 Tegument protein ND 0.39 0.79 0.98 4.45 1.67 38 44 48 62 56 0.03 0.40 2.50 6.23
ORF 68 Glycoprotein ND 0.57 1.24 1.09 4.41 2.91 55 54 53 61 68 0.09 0.54 4.21 4.02
ORF 69 Unknown ND 1.27 3.82 2.73 4.70 1.68 70 71 65 63 58 1.24 4.18 174.18 18.02
ORF 72 v-Cyclin ND 0.39 0.76 0.73 2.74 1.33 39 42 39 53 50 0.15 0.94 121.95 14.89
M11 vBCL-2 ND 0.28 0.58 0.42 2.40 2.13 22 31 20 50 62 0.14 0.39 52.88 6.43
ORF 73 HHV-8 LANA homologue 0.24 1.38 4.55 4.57 12.26 4.35 7 73 72 71 72 72 0.66 1.18 22.83 17.29
ORF 74 vIL8 receptor 0.35 2.98 8.70 10.46 29.76 6.69 9 77 79 77 80 75 4.01 7.47 26.61 67.56
ORF 75c-5′ Tegument protein/FGARAT 0.22 0.85 2.49 2.90 5.68 3.82 6 67 68 66 66 71 0.12 0.57 2.60 2.78
ORF 75c-3′ Tegument protein/FGARAT ND 0.61 1.11 1.78 3.55 0.84 56 52 60 59 27 0.25 1.22 8.47 12.81
ORF 75b-5′ Tegument protein/FGARAT ND 0.28 0.43 0.26 0.95 0.74 23 19 6 19 23 0.05 0.11 0.74 1.03
ORF 75b-3′ Tegument protein/FGARAT 0.11 0.38 0.57 1.03 1.24 0.52 1 37 29 51 28 9 0.05 0.34 0.78 0.89
ORF 75a-5′ Tegument protein/FGARAT 0.40 0.46 0.83 1.18 2.21 1.63 11 45 45 56 47 55 1.00 0.71 5.88 4.17
ORF 75a-3′ Tegument protein/FGARAT ND 0.21 0.40 0.52 1.09 0.82 15 15 27 24 26 0.04 0.13 1.31 1.52
a

ND, not determined; Lung 5d, GAPDH-normalized PI units from the lung of infected mice at 5 dpi; +CHX and −CHX, with and without added CHX, respectively; +PAA and −PAA, with and without added PAA, respectively.