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. 2001 May 15;533(Pt 1):237–252. doi: 10.1111/j.1469-7793.2001.0237b.x

Figure 8. MCH-mediated depression of voltage-dependent calcium channels.

Figure 8

Left traces in A, whole-cell current of calcium channel in BaCl2 bath solution. Traces show the pre-MCH control (1), inhibition induced by MCH (2), a partial return to control levels after 4 min of MCH application (3) and recovery after MCH washout (4). Right panel in A, mean peak IBa before (□), during (Inline graphic) and after (▪) MCH application from all nine neurons is shown. B, whole-cell current of voltage-dependent sodium channels. Experiments were done in the presence of 40 mm TEA and 200 μm CdCl2 in all extracellular solutions and CsCl in the pipette solution. Left traces represent sodium currents prior to (1), during (2) and after (3) MCH application. Right, mean peak INa before (□), during (Inline graphic) and after (▪) MCH application from all seven neurons is shown. C, whole-cell current recordings of voltage dependent potassium channels. Experiments were done in the presence of TTX (1 μm) and CdCl2 (200 μm) in all extracellular solutions. Left traces represent potassium currents prior to (1), during (2) and after (3) MCH application. Right, mean peak IK before (□), during (Inline graphic) and after (▪) MCH application from all seven neurons is shown.