Figure 3. .
Determination of the extent of large deletions in patients with PCWH. Schematic representation of the deletions in patients 2 and 3 was determined by FISH (A) or QMF-PCR (B). A, Representative FISH results. The names of the BACs used for hybridization are indicated on each panel. B, Scheme with the names, positions, and orientation of genes located proximal or distal of SOX10. An approximate scale is shown. BACs used for FISH experiments are shown on the left, and segments analyzed by QMF-PCR are indicated by arrowheads (see table 4 for corresponding primer sequences). QMF-PCR results of patients 2 and 3 are indicated next to the corresponding fragments: + = not deleted; − = deleted.