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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Neuropharmacology. 2007 Jun 26;54(1):213–218. doi: 10.1016/j.neuropharm.2007.05.029

Figure 2. Climbing Fiber activation and CB1R activation is required for LTD under our experimental conditions.

Figure 2

Experiments were conducted as in Figure 1 except that in (A-C) during the conditioning stimulation PFs were stimulated 7 times at 100 Hz without CF activation. Traces from a representative experiment are shown for the response to PF stimulation during the conditioning train (A, left), and the EPSPs before (A, right, black trace) and after the conditioning stimulation (A, right, grey trace). (B) The EPSP is plotted as a function of time for the experiment in (A), and in (C) the EPSP is plotted as a function of time for 6 experiments. (D-F) Experiments were also performed in which PFs were stimulated 7 times at 100 Hz and the CF was stimulated once at time Δt=50 ms in the presence of AM251. Traces from a representative experiment are shown (D), and the EPSP as a function of time are plotted in (E). (F) A summary of the normalized EPSP amplitude as a function of time is summarized for 5 experiments. Error bars in C and F are standard errors.