Table 2.
Functional Classification of Genes Differentially Expressed in Stat3Δ/Δ mice
| GO Classification of Genes Up-regulated in Stat3Δ/Δ mice | |||
| Term | Count | % | PValue |
| Biopolymer modification | 115 | 13.94 | 7.30E-13 |
| Cellular protein metabolism | 164 | 19.88 | 5.83E-10 |
| Protein transport | 52 | 6.30 | 2.49E-07 |
| Phosphate metabolism | 62 | 7.52 | 3.31E-07 |
| Chemotaxis | 17 | 2.06 | 1.38E-06 |
| Protein kinase cascade | 24 | 2.91 | 6.83E-06 |
| Apoptosis | 40 | 4.85 | 1.69E-05 |
| Regulation of apoptosis | 29 | 3.52 | 4.93E-05 |
| Positive regulation of cellular metabolism | 25 | 3.03 | 9.95E-05 |
| Cell migration | 19 | 2.30 | 2.26E-03 |
| Transcription | 106 | 12.85 | 2.64E-03 |
| GO Classification of Genes Down-regulated in Stat3Δ/Δ mice | |||
| Term | Count | % | PValue |
| Cellular lipid metabolism | 33 | 9.97 | 3.60E-13 |
| Lipid biosynthesis | 21 | 6.34 | 3.59E-11 |
| Sterol metabolism | 10 | 3.02 | 2.96E-07 |
| Fatty acid metabolism | 14 | 4.23 | 5.35E-07 |
| Steroid metabolism | 12 | 3.63 | 6.83E-06 |
| Carboxylic acid metabolism | 18 | 5.44 | 5.84E-04 |
| Coenzyme metabolism | 10 | 3.02 | 2.51E-03 |
| Cellular carbohydrate metabolism | 12 | 3.63 | 3.98E-03 |
| Electron transport | 14 | 4.23 | 2.64E-02 |
| Phosphate metabolism | 21 | 6.34 | 3.27E-02 |
Note: Gene Ontology Analysis was preformed using public available web-based tool DAVID [81]. Overrepresented biological processes were selected at the threshold of Fisher Exact Test P-Value ≤ 0.05 and minimum gene counts belonging to an annotation term ≥ 2%.