Table 1.
Clinical history of brain MV donors
| HIV-1 status | ID | Gender/Age (y) | PMI (h) | Neurocognition/Neuropathology | Other autopsy diagnosis |
|---|---|---|---|---|---|
| Neg | N1 | M/35 | 8.5 | Normal/None | Mild Alzheimer type 2 gliosis |
| Neg | N2 | N/A | N/A | Normal/None | N/A |
| Neg | N3 | F/38 | 5.75 | Normal/Not significant | Disseminated, metastatic and poorly differentiated carcinoma |
| Neg | N4 | M/32 | 4.25 | Normal/Not significant | Cystic fibrosis, bronchopneumonia, respiratory and multiorgan failure |
| Neg | N5 | F/46 | 4 | Normal/Not significant | Congenital aortic stenosis with acute myocardial infarction, mild infarction. Two small subependymal microinfarts in the brain |
| Pos (ADC = 0) | P1 | ?/46 | 2.75 | Normal/None | N/A |
| Pos (ADC = 0) | P2 | ?/27 | 8 | Normal/None | N/A |
| Pos (ADC = 0) | P3 | ?/37 | 5 | Normal/None | N/A |
| Pos (ADC = 0) | P4 | M/39 | 11 | Normal/None | Minimal non-diagnostic abnormalities |
| Pos (ADC > 1) | HAD1/D1 | M/30 | 6 | HAD/HIVE | Minimal terminal anoxia |
| Pos (ADC>1) | HAD2/D2 | ?/50 | 21 | HAD/HIVE | N/A |
| Pos (ADC>1) | HAD3/D3 | ?/39 | 12 | HAD/HIVE | N/A |
| Pos (ADC>1) | HAD4/D4 | ?/40 | 12 | HAD/HIVE | N/A |
| Pos (ADC>1) | HAD5/D5 | M/47 | 11 | HAD/HIVE | Anoxic-ischemic encephalopathy, microglial nodule encephalitis, chronic meningoencephalitis with microvascular damage |
Neg indicates HIV seronegative; Pos, HIV seropositive; ADC, AIDS dementia complex; HAD, HIV-associated dementia; HIVE, HIV encephalitis; M, male; F, female; ? or N/A, not available; and PMI, postmortem interval.