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. 2004 Nov;124(5):587–603. doi: 10.1085/jgp.200409023

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Copyright © 2004, The Rockefeller University Press

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Figure 1. — Nonjunctional currents from hCx37 expressed in Xenopus laevis oocytes. (A, top) Currents resulting from a series of voltage steps from a holding potential of −40 mV in 10-mV increments to a potential of +90 mV in an oocyte injected with RNA encoding hCx37 plus AntiCx38. (A, bottom) Currents from an oocyte injected only with AntiCx38. Currents were recorded in 0DivOR2 plus 1 mM Ca²⁺. (B) Average, isochronal (see materials and methods) current–voltage relationship for oocytes injected with hCx37 RNA plus AntiCx38 (▪, n = 10) and oocytes injected only with AntiCx38 (○, n = 3). Currents were recorded in 0DivOR2 plus 0.5 mM Ca²⁺. (C) Normalized, average, isochronal current–voltage relationships for oocytes injected with hCx37 RNA plus AntiCx38, recorded in 0DivOR2 plus 0.5 mM Ca²⁺ in the presence (•, n = 3) or absence (▪, n = 10) of 10 mM 1-heptanol. Currents in the absence of heptanol were corrected by subtracting the mean of the oocytes injected only with AntiCx38. Currents in the presence of heptanol were not corrected by the control currents, since the endogenous sodium current in oocytes was completely inhibited by 10 mM 1-heptanol (not depicted). All currents were normalized to the peak current at +90 mV in the absence of 1-heptanol. The current–voltage relationships were all leak corrected.