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. 2001 Oct 1;118(4):355–376. doi: 10.1085/jgp.118.4.355

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Concentration-dependent effects of dantrolene on thymol-induced calcium release from heavy SR vesicles. Vesicles were actively loaded with calcium and preincubated with dantrolene for 30 min. Calcium release was initiated by the addition of 300 μM thymol. Calcium release was calculated as the maximal rate of rise after the addition of thymol. Data present averages from individual experiments (number of experiments given in parentheses) where the protein content and the amount of calcium loaded into the vesicles were the same. Insets show actual records of calcium release from HSR (bottom) and LSR vesicles (top), monitored as the amount of extravesicular calcium with APIII, from representative experiments at each concentration tested. Transient upward deflections mark the addition of thymol (Thymol). Note that neither thymol nor dantrolene had any effect on LSR vesicles, whereas dantrolene inhibited the thymol-induced calcium release in HSR vesicles.