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. 1999 Jul 1;114(1):13–30. doi: 10.1085/jgp.114.1.13

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Block of Na⁺ current through γS541A ENaC by increasing concentrations of external Li⁺. Data are from outside-out macropatch recordings at a holding potential of −150 mV from Xenopus oocytes expressing γS541A. The bath solution contained 20 mM Na⁺ and increasing concentrations of Li⁺. The amiloride-sensitive currents were normalized to the condition without Li⁺ , shown as mean ± SEM. The fit to a simple inhibition scheme (see methods) taking into account a nonblockable fraction yielded an apparent K _i of 28 mM and is shown as a solid line. The prediction by the 3B2S model (see Table and methods) is shown as a dotted line.

Inline graphic — Block of Na⁺ current through γS541A ENaC by increasing concentrations of external Li⁺. Data are from outside-out macropatch recordings at a holding potential of −150 mV from Xenopus oocytes expressing γS541A. The bath solution contained 20 mM Na⁺ and increasing concentrations of Li⁺. The amiloride-sensitive currents were normalized to the condition without Li⁺ , shown as mean ± SEM. The fit to a simple inhibition scheme (see methods) taking into account a nonblockable fraction yielded an apparent K _i of 28 mM and is shown as a solid line. The prediction by the 3B2S model (see Table and methods) is shown as a dotted line.