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pH Dependence of EAAC1 Affinity for Glutamate
| pH | Extracellular K m | n | Intracellular K m | n |
|---|---|---|---|---|
| μM | μM | |||
| 4.8 | 820 ± 70 | 4 | ||
| 6.0 | 5.8 ± 0.7 | 6 | 34 ± 5 | 10 |
| 7.0 | 9.4 ± 1.8 | 4 | ||
| 7.4 | 5.9 ± 1.3 | 10 | 280 ± 30 | 8 |
| 8.0 | 11 ± 1 | 9 | 580 ± 90 | 8 |
| 9.0 | 36 ± 3 | 8 | ||
| 10.0 | 610 ± 50 580 ± 80* | 10 5 |
Apparent affinity of EAAC1 for glutamate at the extra- and intracellular side as a function of pH. The pipette solution contained thiocyanate. n, number of independent determinations. *Transport current.
