Skip to main content
. 2007 Oct 19;190(1):300–310. doi: 10.1128/JB.01000-07

TABLE 2.

Major virulence-related genes in strains Newman, MW2, and N315 and their locationsa

Type Strain
Newman
MW2
N315
Locus Gene Island Locus Gene Island Locus Gene Island
Toxins
    Enterotoxin NWMN1883 sea φNM3 MW1889 sea φSa3mw SA1761 sep φSa3n
MW1938 sek2 φSa3mw SA1817 sec3 νSa4
MW1937 seq φSa3mw SA1816 sel νSa4
MW0759 sec4 νSa3 SA1642 seg νSaβ
MW0760 sel2 νSa3 SA1643 sen νSaβ
MW0051 seh SA1646 sei νSaβ
SA1647 sem νSaβ
SA1648 seo νSaβ
    Exotoxin NWMN0388 set1nm νSaα MW0382 set16 νSaα SA0382 set6 νSaα
NWMN0389 set2nm νSaα MW0383 set17 νSaα SA0383 set7 νSaα
NWMN0390 set3nm νSaα MW0384 set18 νSaα SA0384 set8 νSaα
NWMN0391 set4nm νSaα MW0385 set19 νSaα SA0385 set9 νSaα
NWMN0392 set5nm νSaα MW0386 set20 νSaα SA0386 set10 νSaα
NWMN0393 set6nm νSaα MW0387 set21 νSaα SA0387 set11 νSaα
NWMN0394 set7nm νSaα MW0388 set22 νSaα SA0388 set12 νSaα
NWMN0395 set8nm νSaα MW0389 set23 νSaα SA0389 set13 νSaα
NWMN0396 set9nm νSaα MW0390 set24 νSaα SA0390 set14 νSaα
NWMN0397 set10nm νSaα MW0391 set25 νSaα SA0393 set15 νSaα
NWMN0400 set11nm νSaα MW0394 set26 νSaα
    Toxic shock syndrome toxin SA1819 tst νSa4
    Exfoliative toxin NWMN1082 eta νSaγ MW1054 eta νSaγ SA1016 eta νSaγ
    Alpha-hemolysin NWMN1073 hly νSaγ MW0955 hly νSaγ SA1007 hly νSaγ
    Beta-hemolysin Truncated hlb φNM3 Truncated hlb φSa3mw Truncated hlb φSa3n
    Delta-hemolysin NWMN1942 hld MW1959 hld SAS065 hld
    Gamma-hemolysin NWMN2318 hlgA MW2342 hlgA SA2207 hlgA
        component NWMN2319 hlgC MW2343 hlgC SA2208 hlgC
NWMN2320 hlgB MW2344 hlgB SA2209 hlgB
    LukDE leukocidin NWMN1717 lukD νSaβ MW1767 lukD νSaβ SA1637 lukD νSaβ
        component NWMN1718 lukE νSaβ MW1768 lukE νSaβ SA1638 lukE νSaβ
    Panton-Valentine leukcidin MW1379 lukS-PV φSa2mw
        component MW1378 lukF-PV φSa2mw
Exoenzymes
    Serine protease NWMN1706 splA νSaβ MW1755 splA νSaβ SA1631 splA νSaβ
NWMN1705 splB νSaβ MW1754 splB νSaβ SA1630 splB νSaβ
NWMN1704 splC νSaβ MW1753 splC νSaβ SA1629 splC νSaβ
NWMN1703 splD νSaβ MW1752 splF νSaβ SA1628 splD νSaβ
NWMN1702 splE νSaβ SA1627 splF νSaβ
NWMN1701 splF νSaβ
NWMN0892 htrA MW0903 htrA SA0879 htrA
    Serine V8 protease NWMN0918 sspA MW0932 sspA SA0901 sspA
    Cysteine protease NWMN0917 sspB MW0931 sspB SA0900 sspB
NWMN0916 sspC MW0930 sspC SA0899 sspC
    Lipase Truncatedg geh φNM4 MW0297 geh SA0309 geh
NWMN2569 lip MW2590 lip SA2463 lip
    Lipase/esterase NWMN0624 lipA MW0617 lipA SA0610 lipA
    Hyaluronate lyase NWMN2106 hysA MW2129 hysA SA2003 hysA
    Thermonuclease NWMN1236 nuc MW1211 nuc SA1160 nuc
Immunomodulators
    Staphylokinase NWMN1880 sak φNM3 MW1885 sak φSa3mw SA1758 sak φSa3n
    Chemotaxis inhibiting protein NWMN1877 chp φNM3 SA1755 chp φSa3n
    Complement inhibitor NWMN1876 scn φNM3 MW1884 scn φSa3mw SA1754 scn φSa3n
    Immunoglobulin G binding protein A NWMN0055 spa MW0084 spa SA0107 spa
    Immunoglobulin G binding protein sbi NWMN2317 sbi MW2341 sbi SA2206 sbi
Adhesins
    Collagen-binding protein MW2612 cna
    Fibronectin-binding protein NWMN2399 fnbAb MW2421 fnbA SA2291 fnbA
NWMN2397 fnbBb MW2420 fnbB SA2290 fnbB
    SD-rich fibrinogen-binding NWMN0756 clfA MW0764 clfA SA0742 clfA
        protein NWMN2529 clfB MW2551 clfB SA2423 clfB
NWMN0523 sdrC MW0516 sdrC SA0519 sdrC
NWMN0524 sdrD MW0517 sdrD SA0520 sdrD
NWMN0525 sdrE MW0518 sdrE SA0521 sdrE
NWMN1940 sdrH MW1956 sdrH SA1839 sdrH
    Elastin-binding protein NWMN1389 ebpS MW1369 ebpS SA1312 ebpS
Other virulence-related phage proteinsc
    Functionally unknown proteinA NWMN0270d φNM4
    Functionally unknown proteinB NWMN0273 φNM4
    Functionally unknown proteinC NWMN0280 φNM4 MW1420 φSa2mw SA1786 φSa3n
    Functionally unknown protein NWMN0284 φNM4
    Functionally unknown protein NWMN0995 φNM2
    Functionally unknown proteinB NWMN1001 φNM2
    Functionally unknown proteinC NWMN1008 φNM2
    Functionally unknown proteinC NWMN1800 φNM1
    Functionally unknown proteinB NWMN1807 φNM1
    Functionally unknown proteinA NWMN1809e φNM1
    Functionally unknown proteinC NWMN1905f φNM3
    Functionally unknown protein NWMN1912 φNM3 MW1924 φSa3mw SA1795 φSa3n
a

Among virulence-related genes shown as red bars in Fig. 1, those involved in capsular polysaccharide biosynthesis and iron uptake are not listed.

b

The C terminus, including cell wall anchoring signal, is truncated, and therefore the product is nonfunctional (11).

c

Identified by bursa aurealis mutagenesis of strain Newman followed by nematode killing assay employing the mutants (4). Unknown proteins with the same superscript capital letter are paralogs.

d

Located between NWMN0270 and NWMN0271.

e

Located between NWMN1809 and NWMN1810.

f

Located between NWMN1905 and NWMN1906.

g

Truncated due to insertion of the indicated prophage.