TABLE 2.
Clusters of regulated genes in the chromosome of M. tuberculosis
| Gene regulation | Cluster no. | Functional category(ies)a | Putative operon(s)b | No. of genes |
|---|---|---|---|---|
| Down regulated at 4 h | 1 | Unknown proteins/PE-PPE | ESAT-6-like | 10 |
| Up regulated at 4 h | 1 | Intermediate metabolism/conserved hypothetical proteins | Hydrogenases | 21 |
| 2 | Lipid metabolism/intermediate metabolism | virS | 23 | |
| 3 | Unknown proteins | 19 | ||
| 4 | Intermediate metabolism/unknown proteins | 19 | ||
| Down regulated at 24 h | 1 | Cell wall/lipid metabolism/PE-PPE | ESAT-6-like | 24 |
| 2 | Cell wall/intermediate metabolism | 17 | ||
| Up regulated at 24 h | 1 | Intermediate metabolism | Hydrogenases | 15 |
| 2 | Cell wall/lipid metabolism/intermediate metabolism | Phthicerol dimycocerosate locus | 35 |
a
Functional categories were obtained from the TubercuList website (www.genolist.pasteur.fr/TubercuList).
b
Putative operons have been defined as groups of genes with intergenic regions of less than 50 bp.