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. 1999 May 1;113(5):661–678. doi: 10.1085/jgp.113.5.661

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Differences in the waveforms of the Ca²⁺-independent, depolarization-activated K⁺ currents in myocytes randomly dispersed from adult mouse (left and right) ventricles. Whole-cell outward K⁺ currents were evoked during 500-ms (A and C) and 4.5-s (B and D) depolarizing voltage steps to potentials between −40 and +60 mV from a holding potential of −70 mV; each trial was preceded by a brief (20 ms) depolarization to −20 mV to eliminate contamination from voltage-gated inward Na⁺ currents not blocked completely by tetrodotoxin (note the inward currents at early times in the records in A and C). The records in A and B were obtained from the same cell, and those in C and D were from the same cell; only the durations of the voltage steps in A and B (and C and D) are different. As is evident, peak outward current amplitudes in A and B are substantially larger than those in C and D. In addition, the decay phases of the outward K⁺ currents in C and D are slower than those in A and B; the rapidly inactivating transient outward K⁺ current, I_to,f, is not evident in the records in C and D (see text). Scale bars: A and B, 4 nA and 55 ms; B and D, 4 nA and 500 ms.