Figure 2.
Example of a validated prediction: falcipain-2–cystatin-A. (A) An interaction was predicted between falcipain-2 and cystatin-A based on a template structure of cathepsin-H (orange) bound to cystatin-A (teal) (PDB 1NB3). (B) The structure of falcipain-2 bound to chicken cystatin was recently experimentally determined (PDB 1YVB). Although the interaction is experimentally verified, the question remains whether it would occur in vivo. Figures were generated by PyMOL (http://www.pymol.org).