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. 2005 Jul 4;202(1):33–45. doi: 10.1084/jem.20050471

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Copyright © 2005, The Rockefeller University Press

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Figure 3. — Induction of promiscuous gene expression in CD80^hi mTECs shows distinct levels of control. (A) The number of differentially expressed genes in the various CD80 subsets indicated is shown by gray regions and the fraction of TRAs contained within these gene pools is shown by red regions. The corresponding relative percentages are given above the bars. (B) Diverse tissue representation by genes induced in the CD80^hi vs. CD80^lo subsets of Aire-deficient mTECs. (C) The curves represent the percentage of genes overexpressed in the different mTEC subsets (mTEC vs. cTEC, CD80^hi vs. CD80^lo of WT and Aire-deficient mice) at the indicated fold changes. Fold changes ≥70 were combined. (D) Verification of gene expression data derived from the microarray analysis by quantitative PCR. Values in parentheses indicate fold changes in the microarray analysis; values on the x axis denote fold changes of the quantitative PCR analysis that were normalized to β-actin expression.