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. 1998 Dec 21;188(12):2301–2311. doi: 10.1084/jem.188.12.2301

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TCR levels and TCR signaling intensity influence CD5 expression on CD4⁺CD8⁺ (DP) thymocytes. (A) Effect of TCR levels on CD5 expression. Histograms depict CD5 and CD3 expression on gated CD4⁺CD8⁺ (DP) thymocytes from TCR-ζ heterozygotes (TCR-ζ^+/−) and TCR-ζ-transgenic mice (TCR-ζ^+/+; ζ tg) relative to control mice (TCR-ζ^+/+). (B) Relationship between TCR signal intensity and CD5 expression. DP thymocytes were stimulated for 18 h on plates coated with the indicated amount of cross-linking antibody (anti-CD3ε; mAb 2C11) then analyzed for CD5 surface expression. (C) Effect of TCR signaling capacity on CD5 expression. Histograms depict CD5 and CD3 surface expression on DP thymocytes from TCR-ζ^−/− mice reconstituted with transgenes encoding either full length ζ chain (ζ-3 ITAM) or ζ chain lacking sequences required for signal transduction (ζ-0 ITAM) (reference 30, see Results). Dotted lines represent staining with control antibody.