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Nuclear Localization and G2-arrest Phenotypes of Various Vpr Genes
| Vpr gene | Wild-type | ATG− | R62P | R80A | ||||
|---|---|---|---|---|---|---|---|---|
| G2-arrest Ability | Positive | Negative | Positive | Negative | ||||
| Subcellular | Nuclear | N/A* | Cytoplasmic | Nuclear | ||||
| localization |
Summary of G2 arrest and nuclear localization phenotypes associated with the wild-type and mutant Vpr-expressing viruses.
The ATG− mutant involved elimination of the Vpr initiation codon and hence did not translate a Vpr product as previously described (21).
