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. 2004 Jul 19;200(2):149–157. doi: 10.1084/jem.20040116

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Copyright © 2004, The Rockefeller University Press

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Figure 1. — Alloactivation induces up-regulation of cell surface GITR on T cells. (A) Sublethally irradiated (750 cGy) syngeneic hosts (C57BL/6 Ly5.1) and allogeneic hosts (BALB/c) were infused with CFSE-labeled donor T cells (C57BL/6). GITR, CD25, and CD44 expression of these donor T cells was determined 3 d after infusion. (B) 9 d after BMT, GITR and CD25 expression was determined on splenic T cells from BALB/c recipients of C57BL/6 TCD-BM (5 × 10⁶) and T cells (0.5 × 10⁶), which were developing GVHD (red histogram). Blue histograms represent untransplanted controls (light blue, C57BL/6; dark blue, BALB/c).