. 2004 Jan 19;199(2):155–166. doi: 10.1084/jem.20031677

Table I.

Cell Type–specific Expression Pattern of Selected Self-antigens Purportedly Associated with Common Autoimmune Diseases

Organ	Autoantigen	Antigen-presenting cell
		cTECs	mTECs	DCs
Pancreas	Insulin^a	−−−−−	+++++	−−−−−
	GAD67^a	−−−−−	+++++	−−−−−
	GAD65^a	−−−−−	−−−−−	−−−−−
	IA-2^a	−−−−−	−++++	−−−−−
Thyroid	Thyroglobulin	−−−−−	+++++	−−−−−
	TPO^a	−−−−−	+++++	−−−−−
Stomach	H/K-ATPase α	−−−−−	+++++	+++++
	H/K-ATPase β	−−−−−	−−−−−	−−−−−
Brain	Golli-MBP	+++++	+++++	+++++
	PLP/DM20	++++−	−++++	−−−−−
	MOG	−−−−−	+++++	−−−−−
Eye	RetSAg^a	−−+−−	+++++	+−−−−
	IRBP^a	−−−−−	+++++	−−−−−
Cartilage	Collagen II	+++−−	++∅++	– ∅ – – –

Expression was analyzed by RT-PCR applying 30–35 cycles. Quantitative differences in signal strength were not considered (see also Fig. S1). +, present; −, absent; ∅, not determined.

The TEC-specific expression pattern of antigens has been confirmed in six additional thymi. In addition, mRNA expression of albumin, α-fetoprotein, C-reactive protein, and erythropoietin in mTECs has been found in six thymi (not depicted).