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FTY impairs but does not abrogate GVL. A separate cohort of mice as described in Figure 6 were evaluated for survival (n = 8 per group). Both FTY-treated and control mice receiving splenocytes survived longer than mice not receiving splenocytes, indicative of a GVL effect (P ≤ .001). However, FTY-treated mice died before controls due to a greater tumor relapse, indicating that FTY impaired GVL effect under these experimental conditions (P = .01).
