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. 1997 Dec 1;186(11):1819–1829. doi: 10.1084/jem.186.11.1819

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IL-12 production by spleen cells in response to stimulation with Toxoplasma antigens in vitro is independent of CD40L or of signals from lymphocytes. Spleen cells from the indicated mouse strains were cultured in the presence of STAg or live T. gondii tachyzoites as in Fig. 1, and IL-12 p40 secreted into supernatants was measured by ELISA after 24 h. C57BL/6 served as controls for the B6-SCID and (B6 × 129)F₂ for the CD40L KO mice. The apparently higher levels of IL-12 production from SCID spleen probably reflect their enrichment for nonlymphoid cells relative to wild-type spleens. Spontaneous IL-12 production by spleen cells cultured in medium alone was not detected. Results represent the mean of triplicate cultures from two to three animals per group. Error bars represent one SD from the mean. Gray bars, STAg; hatched bars, tachyzoites.