Figure 2.
3-aminobenzamide inhibits cell emigration across murine mesenteric postcapillary venules. Mice received 3-aminobenzamide (20 mg/kg i.v.) or PBS (0.1 ml i.v.) immediately before administration of zymosan (1 mg i.p.). Control mice received sterile saline (0.5 ml i.p.). The mesenteries were observed 4 h later (1–3 vessels were analyzed for each animal) quantifying the number of adherent leukocytes per 100 μm vessel length (A) and the number of leukocytes emigrated outside postcapillary venules up to 50 μm from the vessel wall (B). Values are mean ± SEM of six mice per group. *P <0.05 vs. zymosan alone.