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. 1997 Feb 17;185(4):767–776. doi: 10.1084/jem.185.4.767

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DNCB-specific CD4 T cells are found exclusively in the CD45RC⁺ subset of unprimed rats but after sensitization reside in the CD45RC⁻ subset. The latter transfers the effector stage of the DTH response. (a) PVG-RT1^u athymic nude rats received no cells (control) or were injected intravenously with 10 × 10⁶ CD45RC⁺ or 10 × 10⁶ CD45RC⁻ CD4 T cells, purified from TDL of unprimed PVG-RT1^uRT7^b rats. Nude rats were sensitized after 3 wk, ear-challenged 4 d later, and ear thickness measured after 24 h. Histograms represent means ± SD 4, 6, or 4 rats per group (left to right). Test of significance: control vs CD45RC⁺, P <0.001. (b) PVG-RT1^u nude rats received no cells (control) or were injected with 110 × 10⁶ CD45RC⁺, 50 × 10⁶ CD45RC⁻ or 50 × 10⁶ CD45RC⁻/OX40⁻ CD4 T cells purified from LN or TDL of 4-d sensitized PVG-RT1^u-RT7^b rats. LN and TDL results were pooled as no difference was found between them. Rats were ear-challenged immediately after cell transfer and ear thickness measured 24 h later. Histograms are means ± SD of 4, 9, 7 or 4 rats per group (left to right). Test of significance: control vs CD45RC⁺, NS (not significant P >0.05); vs CD45RC⁻ or CD45RC⁻/OX40⁻, P <0.001; CD45RC⁻ vs CD45RC⁻/OX40⁻, NS.