. 1997 Feb 3;185(3):517–530. doi: 10.1084/jem.185.3.517

Table 2.

Kinetics of Peripheral Blood Values of Wild-type, IFN-α/β R^0/0, and IFN-γ R^0/0 Mice after Acute Infection with LCMV-WE

Genotype	Days after infection^*	RBC^‡	Reticulocytes	Platelets	WBC	Neutrophils	Eosinophils	Lymphocytes	Monocytes
Wild type
(Sv129/Ev)	1	9.1 ± 0.5^§	110.2 ± 9.2	635 ± 44	3.3 ± 1.0	0.9 ± 0.2	<0.1	2.4 ± 0.7	<0.1
	3	9.0 ± 0.5	5.2 ± 1.6	216 ± 28	2.7 ± 0.4	0.7 ± 0.1	<0.1	2.0 ± 0.3	<0.1
	7	8.0 ± 0.2	106.5 ± 21.0	381 ± 42	15.1 ± 3.6	7.1 ± 1.7	<0.1	7.6 ± 1.8	0.3 ± 0.1

IFN-α/β R^0/0	1	9.4 ± 0.7	173.7 ± 18.9	650 ± 33	9.3 ± 1.1	2.2 ± 0.4	0.2 ± 0.02	6.5 ± 0.6	0.4 ± 0.03
	3	8.9 ± 0.4	183.8 ± 23.3^‖	530 ± 26^¶	7.1 ± 0.2	2.4 ± 0.7^**	0.1 ± 0.01	4.3 ± 0.2	0.2 ± 0.01
	7	8.6 ± 0.3	217.2 ± 24.9	580 ± 14	10.2 ± 1.2	3.5 ± 0.4	0.2 ± 0.03	6.2 ± 0.8	0.3 ± 0.04

IFN-γ R^0/0	1	9.1 ± 0.2	124.6 ± 25.1	508 ± 34	1.5 ± 0.3	0.4 ± 0.1	<0.1	1.1 ± 0.2	<0.1
	3	9.1 ± 0.3	1.1 ± 1.0^‖	124 ± 11^¶	4.4 ± 0.6	1.2 ± 0.2^**	<0.1	3.1 ± 0.5	<0.1
	7	8.1 ± 0.4	130.5 ± 29.5	374 ± 50	13.7 ± 1.6	2.5 ± 0.4	<0.1	10.5 ± 1.3	0.73 ± 0.15

Sex-matched 8–12-wk-old mice of the indicated genotype (129Sv/Ev background, H-2^b) were infected i.v. with LCMV-WE (2 × 10⁶ PFU per mouse; four mice per group). Blood was collected from the retrobulbar plexus of individual mice at the indicated timepoints. Cellular blood values were quantified in hemocytometer and differential blood counts were determined microscopically from blood smears.

^‡

RBC, total erythrocytes (×10⁹/ml); WBC, total leucocytes (×10⁶/ml); reticulocytes, platelets, neutrophils, eosinophils, lymphocytes, and monocytes (×10⁶/ml).

^§

Data represent means ± SD. Student's t-tests for differences between LCMV-WE–infected IFN-α/β R0/0 vs IFN-γ R^0/0 mice on day 3 after infection:

^‖

P <0.0001;

^¶

P <0.0001;

^**

P <0.01.