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. 2001 Sep 3;194(5):591–600. doi: 10.1084/jem.194.5.591

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Vβ TCR repertoires in chimeras with normal and low T cell numbers. Representation of the different Vβ TCR families by the spleen T cells of different BM chimeras. Mice were reconstituted with either 100% BM cells from normal B6.Ly5^a mice (A) or with a mixture of 1% BM cells from normal B6.Ly5^a mice and 99% BM cells from T cell–deficient B6.Ly5^a/B6.Ly5^bTCRα^−/− donors (B). Each bar represents the percentage of CD3⁺CD4⁺ T cells expressing each Vβ family in individual mice as assessed by flow cytometry. Similar results were obtained with CD3⁺CD8⁺ spleen T cells. Note that although the representation of each Vβ family is identical in all mice reconstituted with 100% BM cells from normal donors, it shows individual variations in mice reconstituted with a limited fraction of competent BM cells.