Table 2.
The Frequency of Thymocyte Subpopulations in Female H-2b/b H-Y and H-2b/b2C Transgenic Mice with or without PD-1 Deficiency
| Genotype | No. of mice examined | Total cell no. | CD4+CD8+ cell no. ×10−6 | CD8+ cell no. ×10−6 | CD4+ cell no. ×10−6 | CD4−CD8− cell no. ×10−6 |
|---|---|---|---|---|---|---|
| ×10−8 | (%) | (%) | (%) | (%) | ||
| H-Y (H-2b/b) | 10 | 1.57 ± 0.44 | 98.07 ± 32.15 | 16 ± 3.89 | 17.74 ± 4.87 | 25.01 ± 7.17 |
| (61.84 ± 4.08) | (10.79 ± 3.70) | (11.51 ± 2.85) | (16.1 ± 2.85) | |||
| H-Y (H-2b/b) × PD-1+/− | 10 | 2.45 ± 0.62 | 168 ± 44 | 23.2 ± 10.8 | 27.47 ± 7.3 | 25.52 ± 11.0 |
| (69.22 ± 6.13) | (9.67 ± 4.40) 0.03 | (11.30 ± 1.78) | (10.12 ± 3.02) | |||
| H-Y (H-2b/b) × PD-1−/− | 15 | 2.41 ± 0.72 | 172 ± 52 | 17.6 ± 7.63 | 27.0 ± 10.0 | 23.44 ± 9.14 |
| (71.62 ± 5.37) | (7.40 ± 2.21) | (11.23 ± 1.87) | (9.75 ± 2.47) | |||
| P values between PD-1+/+ and PD-1−/− background | 0.0001 | 0.0001 | 0.08 | 0.002 | 0.63 | |
| 2C (H-2b/b) | 5 | 0.21 ± 0.09 | 5.72 ± 2.74 | 6.00 ± 2.78 | 1.46 ± 0.55 | 8.15 ± 2.82 |
| (26.1 ± 4.7) | (28.0 ± 4.1) | (6.9 ± 0.8) | (39.0 ± 6.8) | |||
| 2C (H-2b/b) × PD-1−/− | 5 | 0.19 ± 0.05 | 6.28 ± 1.74 | 3.33 ± 1.08 | 2.64 ± 0.84 | 6.91 ± 2.06 |
| (34.0 ± 3.6) | (17.3 ± 1.7) | (13.8 ± 1.4) | (36.0 ± 3.7) | |||
| P values between PD-1+/+ and PD-1−/− background | 0.36 | 0.35 | 0.05 | 0.017 | 0.23 |
Numbers in parentheses indicate percentages of subsets based on the expression of CD4 and CD8. All numbers are shown as mean ± SD.