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. 1999 Nov 15;190(10):1479–1492. doi: 10.1084/jem.190.10.1479

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Histopathological alterations and TNF-α mRNA expression before clinical onset of colitis. Day 10 after transfer of TNF^+/+CD4⁺CD45RB^hi T cells into TNF^+/+RAG2^−/− recipients (A and B); TNF^−/−CD4⁺CD45RB^hi T cells into TNF^+/+RAG2^−/− recipients (C and D); and TNF^+/+CD4⁺CD45RB^hi T cells into TNF^−/−RAG2^−/− recipients (E and F). A, C, and E, hematoxylin and eosin staining; B, D, and F, in situ hybridization; magnification 60.