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. 1999 Oct 18;190(8):1165–1174. doi: 10.1084/jem.190.8.1165

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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T cell dependence of VSV-specific IgM antibody responses. Control (C57BL/6 × 129Sv)F1 (A), C3^−/− (B), C4^−/− (C), CR2^−/− (D), and CD19^−/− (E) were infected with 2 × 10⁶ pfu VSV. Total VSV-neutralizing Ig was assessed at the time points indicated. Mice were either depleted of CD4⁺ T cells (two 200-μl administrations of anti-CD4 antibody YTS191.1, on day 3 and day 1) or left untreated. Efficiency of CD4⁺ T cell depletion was checked by FACS™. Neutralizing IgG (circles) was assessed on day 8 (reduction with β-ME) and was always at least two titer steps lower than total Ig, indicating that antibody titers up to day 8 represent IgM. One of three comparable experiments is shown.