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. 1999 Jul 1;190(1):65–74. doi: 10.1084/jem.190.1.65

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Fas-independent negative selection induced by low doses of SEB in vivo is defective in CD28^−/ ⁻ and CD43^−/ ⁻ mice. Mice on a BALB/c (H-2^d) background were injected with graded doses of SEB; on day 2, thymocytes were stained and analyzed as in Fig. 6. The data show total numbers of Vβ8⁺ and Vβ6⁺ cells/mouse (three to five mice per group) at the level of HSA^hiCD4⁺8⁻ cells. The data refer to (A) cells from normal CD28^+/+43^+/+ (□), CD28^−/ ⁻43^+/+ (○), and CD28^+/+43^−/ ⁻ (▵) mice and to (B) CD28^+/+43^+/+ lpr/lpr (▪), CD28^−/ ⁻43^+/+ lpr/lpr (•), and CD28^+/+43^−/ ⁻ lpr/lpr (▴) mice.