Figure 5.
Telomere fusions arise in ArtN/N ES cells. (A) Telomeric sequence was identified using a Cy3-labeled peptide nucleic acid probe in metaphases from ArtN/N, DNA-PKcsN/N, and TC1 ES cells. (B) Representative short-arm telomeric fusion in an ArtN/N ES cell metaphase. Arrow represents two telomeric signals located at the point of fusion between cytogenetically invisible short arms. Adjacent, nonfused chromosomes would show four discrete signals.
