Figure 2.

Anti-T1/ST2 treatment prevents RSV-induced weight loss during immune responses dominated by Th2-driven eosinophilia. Mice were primed with Gvac, Fvac, or β gal-vac and challenged with RSV intranasally 14 d later. Half of each group was given anti-T1/ST2 antibody daily from the day before intranasal RSV challenge (open symbols), whereas the other half was given isotype-matched irrelevant antibody (closed symbols). The percent weight loss or gain on subsequent days was calculated from the original weight of each individual mouse. The mean and standard deviation of five individual mice are shown (A). The data for β gal/RSV mice treated with anti-T1/ST2 is not shown for clarity, but weight loss was not significantly different from control treated β gal/RSV mice. In B, a separate experiment with just G/RSV-infected mice is shown. Each line represents an individual mouse treated with anti-T1/ST2 (dotted line) or irrelevant isotype-matched control (solid line).