Table 2.
Reproductive steroid and hormone averages for PMDD (n = 68) and control (n = 47) subjects completing menstrual cycle serum sampling and between-group comparison
| Measure | PMDD | Control | P value |
|---|---|---|---|
| Serum LH (IU/liter) | 10.9 ± 4.0 (9.9–11.9) | 11.5 ± 5.3 (10.0–13.1) | 0.52 |
| Serum LH peak (IU/liter) | 33.5 ± 23.5 (27.8–39.2) | 34.2 ± 23.6 (27.1–41.3) | 0.29 |
| Luteal phase LH (IU/liter) | 5.7 ± 14.7 (4.2–7.2) | 7.5 ± 18.0 (5.7–9.3) | 0.064 |
| Serum SHBG (nmol/liter) | 61.4 ± 25.1 (55.4–67.5) | 52.4 ± 21.3 (46.2–58.7) | 0.046 |
| Serum albumin (g/dl) | 4.4 ± 0.2 (4.3–4.4) | 4.3 ± 0.21 (4.26–4.39) | 0.24 |
| Serum progesterone (ng/ml) | 366.2 ± 164 (326–406) | 346.4 ± 181.2 (293–400) | 0.34 |
| Luteal phase progesterone (ng/ml) | 1110 ± 769 (1034–1187) | 1143 ± 940 (1050–1235) | 0.59 |
| Serum E2 (pg/ml) | 153.2 ± 46.4 (142–164) | 150 ± 57.8 (133–167) | 0.76 |
| Serum E2 peak (pg/ml) | 276.4 ± 125 (246–306.7) | 261.0 ± 143 (218.1–303.9) | 0.55 |
| Free E2 (calculated pmol/liter) | 7.7 ± 2.4 (7.1–8.3) | 8.0 ± 2.3 (7.3–8.7) | 0.52 |
| Percent free E2 (calculated) | 1.39 ± 0.26 (1.32–1.45) | 1.50 ± 0.28 (1.41–1.58) | 0.03 |
| E2 bound to SHBG (calculated pmol/liter) | 257 ± 108 (231–283) | 239 ± 139 (199–280) | 0.45 |
| Percent E2 bound to SHBG (calculated) | 45.1 ± 9.7 (45.8- 47.5) | 41.5 ± 10.3 (38.5–44.5) | 0.05 |
| E2 bound to albumin (calculated pmol/liter) | 298 ± 91.7 (249–288) | 304 ± 86 (279–329) | 0.71 |
| Percent E2 bound to albumin (calculated) | 53.5 ± 9.4 (51.2–55.7) | 57.0 ± 10.1 (54.1–60.0) | 0.06 |
| Luteal phase E2 (pg/ml) | 156 ± 134 (141–171) | 170 ± 164 (152–189) | 0.238 |
| Luteal phase free E2 (calculated pmol/liter) | 7.6 ± 7.0 (6.8–8.3) | 8.9 ± 8.4 (8.0–9.8) | 0.032 |
| Luteal phase percent free E2 (calculated) | 1.35 ± 0.35 (1.28–1.41) | 1.47 ± 0.43 (1.39–1.55) | 0.018 |
Values are expressed as mean ± sd (95% confidence interval). The Student’s t test comparison of differences between-group means was performed. To convert E2 pg/ml to pmol/liter, multiply by 3.67.