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. 2000 Jul 10;150(1):1–12. doi: 10.1083/jcb.150.1.1

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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cmet^Δ embryos cannot maintain metaphase chromosome alignment. Embryos carrying cmet^Δ as the only copy of CENP-meta were collected and observed in real-time. Chromosomes are visible due to incorporation of histone-2A-variant-GFP. Chromosomes (pseudo-colored red in A, green in B, and orange in C) lose initial alignment, becoming chronically misaligned. Most misaligned chromosomes do not disjoin into separate chromatids and both sisters segregate together to the same pole in anaphase. Numbers indicate relative elapsed time in seconds; yellow dotted lines in 0 time panels indicate approximate direction of spindle axis in nucleus being displayed. Each panel is a 20-μm square. Video 3 is available at http://www.jcb.org/cgi/content/full/150/1/1/DC1.