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. 2003 Nov 24;163(4):889–899. doi: 10.1083/jcb.200307068

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Copyright © 2003, The Rockefeller University Press

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Figure 4. — CaMKII/Cre:fLAMγ1 mice have motor dysfunction. The mouse on the left was homozygous for the fLAMγ1 allele, but did not contain the CaMKII-Cre gene. Mice of this genotype or mice heterozygous for the fLAMγ1 allele and carrying the CaMKII-Cre gene were always normal. The mouse on the right (Mutant) was homozygous for the fLAMγ1 allele and carried the CaMKII-Cre gene. These mice were smaller and exhibited muscle weakness and in most cases complete paralysis of the legs (arrows) and muscular atrophy.